John S. Lazo

 

Professor, Department of Pharmacology

10045 Biomedical Science Tower 3
412-648-9200, 9009(fax)
lazo@pitt.edu
http://pharmacology.medicine.pitt.edu/personnelDetail.asp?pid=761&id=145&ptype=2&pnavcat=2&subpc=

 

 

John Lazo’s laboratory primarily focuses on studying how protein phosphatases control mammalian cell division and survival. At a nanoscale, these protein phosphatases control cell motility, spindle function, microtubule movement, intracellular cargo transfer, and cellular invasion. Additionally, Lazo is engaged at the new Drug Discovery Institute in the identification of new pharmacologically interesting small molecules. The design and development of robust nanoscale assays using optical endpoints are of particular interest for this effort.

 

 

 

 

 

 

 

 

 

 

 

Binding model of a novel small molecule inhibitor of the protein phosphatase Cdc25B.