Angela Gronenborn

 

Professor, Department of Structural Biology

1050 Biomedical Science Tower 3

412-648-9959, 9008(fax)

amg100@pitt.edu

http://www.structbio.pitt.edu/drupal-5/?q=angela-gronenborn

 

 

The ability to manipulate protein function in a rational manner offers the tantalizing possibility of creating new proteins with properties that impart biomedial and biotechnological value. For example, proteins can be re-designed to improve the stability, activity, safety and biodistribution for therapeutic uses, and, in some cases, the promise of lower manufacturing costs may also be of consideration. Angela Gronenborn’s research uses protein design for testing general theories of structure and function. In vitro protein design and in vivo protein evolution approaches are employed to evaluate our current understanding of the general rules governing protein architecture and basic principles of protein-protein and protein-ligand interactions.

 

 

 

 

 

 

 

 

 

Single amino acid changes lead to drastic structural rearrangements.